HUNSEN GROUP RESEARCH INTERESTS

Carbohydrates are one of the most abundant organic compounds in nature.  In addition they possess a tremendous amount of structural diversity.  The research endeavor being undertaken in Hunsen’s Lab focuses on tapping the abundance and rich structure of carbohydrates and other natural products. 

The projects currently under investigation in this lab are:

  1. Design, synthesis, biological activity studies of natural product based drugs for cancer prevention and treatment.
  2. Pharmacoproteomics study of  the mechanism of action of natural products on cancer cells.
  3. Carbohydrate Chemistry
  4. Green Chemistry: Green oxidation reactions and Enzyme catalyzed polymerization reactions

PUBLICATIONS

 

1.    Hunsen, Mo.  “Functional polyesters and copolymers by a one-pot acetylation/oxidation of Cellulose,” Chapter 18, in Materials, Chemicals and Energy from Forest Biomass, Argyropoulos, D. S. Eds., ACS Symposium Series, 2007.

2.    Hunsen, Mo.  “Pyridinium chlorochromate catalyzed oxidation of alcohols to aldehydes and ketones,” Tetrahedron Letters, 2005, 46, 1651-1653.          (Also on CHEMINFORM).

-   Best Synthetic Methods: Oxidation” on www.Organic-Chemistry.Org  and 

-  “Top 25 most downloaded Tetrahedron Letters article in 2005.”

3.    Hunsen, Mo.  “Carboxylic acids from primary alcohols and aldehydes by a Pyridinium chlorochromate catalyzed oxidation,” Synthesis 2005, 2487-2490.         (Also on CHEMINFORM).

-  Featured on www.Organic-Chemistry.Org 

4.    Hunsen, Mo.  “Monosaccharide Cycles: A method to determine the general stereochemical relationships of both D and L monosaccharides,” The Chemical Education Journal 2006, 9, No. 1.

5.    Hunsen, Mo; Long, David A.; D’Ardenne, Christopher R.; and Smith, Amanda L.  “Mild one-pot preparation of glycosyl bromides,” Carbohydr. Res. 2005, 340, 2670-2674.

- “A Top 25 most downloaded Carbohydrate Research article.”

6.    Hunsen, Mo.  “Pyridinium fluorochromate catalyzed oxidation of alcohols and aldehydes,” J. Fluor. Chem. 2005, 126, 1356-1360. (Also on CHEMINFORM).

7.    Temelkoff, D. P.; Smith, C. R.; Kibler, D. A.; McKee, A.; Duncan, S.; Zeller, M.;  Hunsen, M.; and Norris, P. “Application of Bis(diphenylphosphino)ethane in Staudinger-type N-Glycosyl Amide Synthesis,” Carbohydr. Res.  2006, 341, 1645-56.

8.    Hunsen, Mo; Mitchell, Josh M.; Packer, Kyle T. “Hexafluoro-2-hydroxyisobutyric acid,” in Encyclopedia of Reagents in Organic Synthesis. 2007, DOI: 10.1002/047084289X.m00733.

9.    Hunsen, Mo; Packer, Kyle T.; Mitchell, Josh M. “Methyl 2,2-diFluoro-2-Iodoacetate,” in Encyclopedia of Reagents in Organic Synthesis. 2007, DOI: 10.1002/047084289X.m00734.

10. Hunsen, Mo; Azim, Abul; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. “Lactone ring-opening polymerization catalyzed by a cutinase biocatalyst,” American Chemical Society Polymer Preprint 2006, 47 (2), 253.

11. Azim, Abul; Hunsen, Mo; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. “Cutinase: a new biocatalyst for polyester synthesis via polycondensation reactions,” American Chemical Society Polymer Preprint 2006, 47 (2), 226.

12. Hunsen, Mo.  “1,2,3-Oxadiazines and 1,2,3-Thiadiazines.” In Comprehensive Heterocyclic Chemistry III, AR Katritzky, CA Ramsden, EFV Scriven and RJK Taylor, Eds.; Elsevier: Oxford, 2008; Vol. 9, pp 291 - 300

13. Hunsen, Mo; Azim, Abul; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. “A Cutinase with Polyester Synthesis Activity,” Macromolecules, 2007, 40, 148.

14. Hunsen, Mo; Azim, Abul; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. “Cutinase: A Powerful Biocatalyst for Polyester Synthesis by Polycondensation of diols and diacids and ROP of lactones,” ACS Symposium series 2008, 17, 263-274.

15. Hunsen, Mo; Azim, Abul; Xie, Wenchun; and Gross, Richard A. “Humicola insolens Cutinase-Catalyzed Lactone Ring-Opening Polymerizations: Kinetics and Mechanistic Studies,” Biomacromolecules 2008, 9, 518-522.

 

RECENT PRESENTATIONS AND INVITED LECTURES 

 

27.  Hunsen, Mo.  2008.  “Natural Product Chemistry.” (Invited seminar at Hunter College, NY).

26.  Hunsen, Mo.  2008.  “Natural Product Chemistry.” (Invited seminar at University of Alabama, AL).

25.  Hunsen, Mo; Azim, Abul; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. 2006. “Lactone ring-opening polymerization catalyzed by a cutinase biocatalyst,” Abstracts of papers of the American Chemical Society 232, 446-POLY.

24.  Azim, Abul; Hunsen, Mo; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. 2006. “Cutinase: a new biocatalyst for polyester synthesis via polycondensation reactions,” Abstracts of papers of the American Chemical Society 232, 675-POLY.

23.  Hunsen, Mo.  2006.  “Green Chemistry: Chemical & Enzymatic Catalysis,” (Invited seminar at Youngstown State University, OH).

 22. Hunsen, Mo; Burke, Kelly, P.; D'Ardenne, Christopher R. 2006.  “Novel carbohydrate-tethered carboplatin analogs,” Abstracts of papers of the American Chemical Society 231, 269-MEDI.

21.  Hunsen, Mo.  2006.  “Chromium-catalyzed oxone® oxidation of alcohols,” Abstracts of papers of the American Chemical Society 231, 581-ORGN.

20.  Hunsen, Mo; D'Ardenne, Christopher R.; Burke, Kelly, P. 2006. “Carboxyalkyl Gycosides via OsO4 catalyzed Oxone® oxidation: Synthesis of carbohydrate-tethered cisplatin analogs,” Abstracts of Papers of the American Chemical Society 231, 61-CARB.

19.  Hunsen, Mo.  2006.  “Halochromate catalyzed oxidation of sulfides,” Abstracts of papers of the American Chemical Society 231, 512-INOR.

18.  Hunsen, Mo.  2005.  “Green Chemistry via Chemical and Enzymatic Catalysis,” (Science Division Colloquium at Kenyon College, Gambier, OH).

17.  Long, David, A.; D’Ardenne, Christopher; Smith, Amanda S.; Hunsen, Mo. 2005. “Mild one-pot preparation of glycosyl bromides,” 1st Midwest Carbohydrate Symposium, Toledo, OH.

16.  Hunsen, Mo.  2005.  “Functional polyesters and copolymers by a one-pot acetylation/oxidation of Cellulose,” PACIFICHEM, Honolulu, HI.

15.  Hunsen, Mo.  2005.  “Halochromate catalyzed oxidation of alcohols and aldehydes,” 2nd Int'l Conference on Green and Sustainable Chemistry and 9th Annual Green Chemistry and Engineering Conference.

14.  Hunsen, Mo.  2005.  “Introducing green chemistry in sophomore organic chemistry             lectures and laboratories,” 2nd Int'l Conference on Green and Sustainable Chemistry and 9th Annual Green Chemistry and Engineering Conference.

13.  Hunsen, Mo.  2005.  “Cr (VI)-catalyzed oxidation of sugars: Functionalized polyhydroxycaproate via a one-pot acetylation/oxidation of cellulose,” Abstracts of papers of the American Chemical Society 229, 41-CELL.

12.  Hunsen, Mo; Long, David, A.; D’Ardenne, Christopher; and Bente, Katharine, L. 2005.  “Facile acetobromination of sugars and hydrobromination of alkenes via in situ generation of HBr,” Abstracts of papers of the American Chemical Society 229, 65-CARB.

11.  Hunsen, Mo.  2005.  “Pyridinium chlorochromate-catalyzed oxidation of alcohols and aldehydes,” Abstracts of papers of the American Chemical Society 229, 946-ORGN.

10.  Norris, Peter; Temelkoff, David; Smith, Craig; Zeller, Mathias; and Hunsen, Mo. 2005. “Synthesis and structures of pyranose N-glycosyl amides and triazoles,” Abstracts of papers of the American Chemical Society 229, 78-CARB. 

9.    Hunsen, Mo.  2005.  “Green Oxidation Reactions.”  (Polytechnic University, Brooklyn, NY).

8.    Morgan, B. J. and Hunsen, Mo.  2004.  “Synthesis and inhibition studies of novel glycosidase inhibitors.” Abstracts of papers of the National Undergraduate Symposium, Indianapolis, IN.

7.    Hunsen, Mo.  2004.  “Synthesis and inhibition studies of novel glycosidase inhibitors.” (Invited talk at Univ. of Toledo). 

6.    Hunsen, Mo.  2004.  “Synthesis and inhibition studies of novel glycosidase inhibitors.” (Invited talk at Wright State Univ. Dayton, OH).

5.    Hunsen, Mo.  2004.  “Green Chemistry and Carbohydrates.” (Science Division Colloquium, Kenyon College, Gambier, OH).

4.    Hunsen, Mo.  2004.  “Monosaccharide cycles: A simple method to determine the stereochemical relationships of monosaccharides,” Abstracts of papers of the American Chemical Society 228, 56-CHED.

3.    Hunsen, Mo.  2003.  “Conformation and dynamics of 3,6-anhydrosugars,” Abstracts of papers of the American Chemical Society 226, 50-CARB.

2.    Hunsen, Mo.  2002.  “MM and semi-empirical calculation, MD simulation, and NMR spectroscopy studies on the conformations of the building units of agarose and carrageenan,” Abstracts of papers of the American Chemical Society 224, 89-CARB.

1.    Hunsen, Mo.  2002.  “Conformational analysis of di- and tetrasaccharides containing 3,6-anhydro-α-galactopyranose units,” Abstracts of papers of the American Chemical Society 224, 62-CARB.

 

HUNSEN GROUP PAST AND PRESENT MEMBERS (CURRENT ADDRESS)

  1. Sara Collins `04 (Columbus, OH)
  2. Nikki Oyelakin `04
  3. Barbara Morgan `04 (PhD student at U of Pennsylvania, Chemistry)
  4. Trey Smith `04 (U of Pittsburgh, Pharmacology)
  5. Amanda Smith `04 (Harvard Medical School)
  6. Bryan Bonder `05 (MD student at U Toledo)
  7. Tim Rust `05 (MD student at Wright State U)
  8. Meilyn Chan `05
  9. Kelly Burke `06 (MD/PhD student at Johns Hopkins U)
  10. Chris D’Ardene `06 (MD student at Boston U)
  11. David Long `07 (PhD Student at Cal Tech)
  12. Katharine Bente `07
  13. Audrey Eisenberg `07

MAJOR AWARDS OF HUNSEN GROUP MEMBERS (AWARD)

  1. Prof. Mo Hunsen (DAAD Fellow, Tomsich Science Award, Henry – Dreyfus Award)
  2. Barbara Morgan `04 (ACS – Senior Award,  ACS – Polymer Award, ACS - Organic Division Fellowship)
  3. Amanda Smith `04 (ACS – Junior Award, Gordon Johnson Research Award)
  4. Sara Collins `04 (Carl Djerrasi Award)
  5. Bryan Bonder `05 (Ohio State Univ. SURF)
  6. Tim Rust `05 (Pfizer SURF)
  7. Kelly Burke `06 (Goldwater Scholarship, ACS – Polymer Award, Mayo SURF)
  8. David Long `07 (Goldwater Scholarship, Udall Scholarship, NSF Felllow, DOD Fellow, ACS – Polymer Award, Franklin Miller Award)
  9. Chris D’Ardenne `06 (Franklin Miller Award, Gordon Johnson Research Award)

http://chemistry.kenyon.edu/hunsen/ResearchInterests_2005_files/image001.jpg

Group Photo with Summer Science Fellows

From left to right: BJ Morgan ‘04, Amanda Smith ‘04,

Tim Rust ‘05, and Prof. Mo Hunsen